...in Two Rivers
• William S. Aiken, Jr. – Congressman, D-SC, former governor of SC, owner of Jehossee Plantation
• Harriet Aiken – wife of William
• Henrietta Aiken – daughter of William and Harriet
• Andrew Burnet Rhett, Sr. – husband of Henrietta
• Daniel Alexander Payne – an American bishop, educator, college administrator and author
• Toussaint Louverture – architect of successful Haitian Revolution
• Jean-Jacques Dessalines – protegee of Toussaint Louverture and first black ruler of Haiti
• Denmark Vesey – convicted and executed for planning a major slave revolt in Charleston, South Carolina
• Gabriel Prosser – convicted and executed for planning a large slave rebellion in Richmond, Virginia
• James Gadsden – United States Ambassador to Mexico (Gadsden Purchase)
• John Schnierle – Mayor of Charleston
• T. Leger Hutchinson – Mayor of Charleston
• Robert Barnwell Rhett, Jr. – Publisher of the Charleston Mercury newspaper
• Robert Smalls – an American politician, publisher, businessman, and maritime pilot
• Nat Turner — an American preacher who led a rebellion of enslaved and free black people in Southampton County, Virginia
• Franklin Pierce – President of the United States
• John C. Calhoun – Vice President, Secretary of State, Secretary of War, Senator, Congressman
• James Monroe – Governor of Virginia
• John Lyde Wilson – Governor of South Carolina
• Thomas Affleck – published popular account-books; example: The Cotton Plantation Record and Account Book
• Eliza Seymour Lee – famous caterer and owner of the Lee House Restaurant
